Adjunct in peptic ulcer
Adult: 25-50 mg 4 times daily, titrated to the lowest effective dose and adjust accordingly to patient’s response.
Chỉ định và Liều dùng
Oral
Adjunct in peptic ulcer Adult: 25-50 mg 4 times daily, titrated to the lowest effective dose and adjust accordingly to patient’s response.
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Cách dùng
Should be taken with food.
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Chống chỉ định
Hypersentivity. Glaucoma, obstructive uropathy and GI disease, paralytic ileus, myasthenia gravis, unstable CV status in acute GI haemorrhage, intestinal atony, toxic megacolon complicating ulcerative colitis.
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Thận trọng
Patient w/ autonomic neuropathy, ulcerative colitis, CV disease (e.g. coronary heart disease, CHF, cardiac arrhythmias, tachycardia, HTN), prostatic hypertrophy, hyperthyroidism. Renal and hepatic environment. Elderly, debilitated patients. Pregnancy and lactation.
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Tác dụng không mong muốn
Significant: Drowsiness, blurred vision, diarrhoea, heat prostration, psyschosis.
Nervous: Dizziness, headache, nervousness, confusion, insomnia, weakness. CV: Tachycardia, palpitations. GI: Vomiting, nausea, constipation, ageusia, bloating, xerostomia. Endocrine: Decreased lactation. Genitourinary: Urinary retention, urinary hesitancy, impotence. Ophthalmologic: Increased ocular tension, cycloplegia, mydriasis. Dermatologic: Urticaria, hypohidrosis. Potentially Fatal: Anaphylaxis. |
Thông tin tư vấn bệnh nhân
This drug may cause drowsiness and blurred vision, if affected, do not drive or operate machinery.
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Quá liều
Symptoms: Curare-like effects (e.g. neuromuscular blockade leading to weakness and possible paralysis), headache, nausea, vomiting, blurred vision, mydriasis, hot and dry skin, xerostomia, difficulty in swallowing, dizziness, CNS stimulation. Management: Employ gastric lavage, admin of emetics and activated charcoal. May use sedatives (e.g. short-acting barbiturates, benzodiazepines) for overt signs of excitement. If indicated, may also use parenteral cholinergic agent as antidote.
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Tương tác
May increase adverse effects of other anticholinergic drugs (e.g. amantadine, class I antiarrhythmic agents, antihistamines, antipsychotic agents, benzodiazepines, MAOIs, narcotic analgesics, nitrates and nitrites, sympathomimetic agents, TCA). May antagonise effects of antiglaucoma agents and drugs which alter GI motility (e.g. metoclopramide). Increased serum digoxin concentration and toxicity.
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Tác dụng
Description:
Mechanism of Action: Mepenzolate bromide is an antimuscarinic agent and a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses colon contraction. Pharmacokinetics: Absorption: Incompletely absorbed from the GI tract. Excretion: Via urine (3-22%) and faeces. |
Đặc tính
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Bảo quản
Store below 30°C. Protect from heat.
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Phân loại MIMS
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Phân loại ATC
A03AB12 - mepenzolate ; Belongs to the class of synthetic anticholinergics, quaternary ammonium compounds. Used in the treatment of functional bowel disorders.
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Tài liệu tham khảo
Anon. Mepenzolate. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 19/07/2017. Buckingham R (ed). Mepenzolate Bromide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 19/07/2017. Cantil Tablet (Sanofi-Aventis U.S LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 19/07/2017. McEvoy GK, Snow EK, Miller J et al (eds). Mepenzolate Bromide. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 19/07/2017.
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